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| Alzheimer's & Dementia: The Journal of the Alzheimer's Association |
| Volume 4, Issue 1, Supplement 1 (January 2008) |
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| Leon Thal Symposium on the Prevention of Dementia
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Editorial
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Leon Joel Thal, MD, 1944–2007: Honoring his scientific legacy, 21 December 2007
Zaven S. Khachaturian
pages S1-S3
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Perspectives
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Leon Thal and the therapeutic age of Alzheimer’s disease
Paul S. Aisen
pages S4-S6
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Chronic disease long-term drug prevention trials: Lessons from the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT), 21 December 2007
Curtis L. Meinert, John C.S. Breitner
pages S7-S14
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Optimizing phase II of drug development for disease-modifying compounds
Jeffrey L. Cummings
pages S15-S20
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We should not distinguish between symptomatic and disease-modifying treatments in Alzheimer’s disease drug development, 21 December 2007
Rachelle S. Doody
pages S21-S25
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Drug discovery and the prevention of Alzheimer’s disease, 21 December 2007
Howard Fillit
pages S26-S28
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Realizing the potential of positron emission tomography with 18F-fluorodeoxyglucose to improve the treatment of Alzheimer’s disease, 21 December 2007
Norman L. Foster, Angela Y. Wang, Tolga Tasdizen, P. Thomas Fletcher, John M. Hoffman, Robert A. Koeppe
pages S29-S36
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Eyes on the prize: Federal Alzheimer’s research effort aims to facilitate interventions, 21 December 2007
Richard J. Hodes, Neil Buckholtz, Vicky Cahan, Marcelle Morrison-Bogorad
pages S37-S47
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Current and future management of Alzheimer’s disease, 21 December 2007
Serge Gauthier, Judes Poirier
pages S48-S50
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A quarter century of advancing treatment for Alzheimer’s disease with Leon J. Thal, 21 December 2007
Michael Grundman
pages S51-S55
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The oldest old and the 90+ Study, 21 December 2007
Claudia H. Kawas
pages S56-S59
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Home-based technologies: A new paradigm for conducting dementia prevention trials, 21 December 2007
Jeffrey Kaye
pages S60-S66
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Differentiating Alzheimer’s disease from dementia with Lewy bodies and Parkinson’s disease with (+)-[11C]dihydrotetrabenazine positron emission tomography
Robert A. Koeppe, Sid Gilman, Larry Junck, Kris Wernette, Kirk A. Frey
pages S67-S76
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Dementia: Is it time for a change in focus?, 21 December 2007
Lewis H. Kuller, Oscar L. Lopez
pages S77-S84
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A perspective on risks that impede development of drugs to modify the course of Alzheimer’s disease: Can they be reduced?, 21 December 2007
Richard C. Mohs
pages S85-S87
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Challenges in clinical research on Alzheimer’s disease: Leon Thal’s legacy, 21 December 2007
Ronald C. Petersen
pages S88-S90
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Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer’s disease
Judes Poirier
pages S91-S97
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The pre–mild cognitive impairment, subjective cognitive impairment stage of Alzheimer’s disease
Barry Reisberg, Leslie Prichep, Lisa Mosconi, E. Roy John, Lidia Glodzik-Sobanska, Istvan Boksay, Isabel Monteiro, Carol Torossian, Alok Vedvyas, Nauman Ashraf, Imran A. Jamil, Mony J. de Leon
pages S98-S108
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Disease-modifying approaches to Alzheimer’s disease: Challenges and opportunities—Lessons from donepezil therapy
Marwan N. Sabbagh, Sharon Richardson, Norman Relkin
pages S109-S118
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Current challenges for the successful treatment and prevention of Alzheimer’s disease: Treating the pathologies of the disease to change its clinical course, 21 December 2007
Dale Schenk
pages S119-S121
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Prevention therapeutics of dementia, 21 December 2007
Lon S. Schneider
pages S122-S130
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More than a decade of estrogen neuroprotection, 21 December 2007
James W. Simpkins, Meharvan Singh
pages S131-S136
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Electroencephalography and event-related potentials as biomarkers of mild cognitive impairment and mild Alzheimer’s disease, 21 December 2007
Colleen E. Jackson, Peter J. Snyder
pages S137-S143
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Memory health clinics—a first step to prevention, 21 December 2007
Bruno Vellas, Sophie Gillette-Guyonnet, Sandrine Andrieu
pages S144-S149
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Leon Thal’s vision for the treatment and prevention of Alzheimer’s disease
Michael W. Weiner
pages S150-S152
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Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses, 21 December 2007
Mehmet Cansev, Richard J. Wurtman, Toshimasa Sakamoto, Ismail H. Ulus
pages S153-S168
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Frontmatter
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Subscriber information page
page A2
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Contents
page A3
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Contents
page A4
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Editorial board
page A5
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Medical and scientific advisory council
page A6
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